A dialog between Donald MacKay and Mario Bunge, printed in the journal Neuroscience over the course of two years beginning in 1977, provides a conscise summary of MacKay's views on the mind-body relationship. In this dialog, MacKay contrasts the dualistic interactionism theory of Popper and Eccles with Bunge's emergentist materialism theory, and then builds a case for a third alternative based on the notion of mental events embodied in, but not identical to, brain events. Although neuroscience has made tremendous progress (...) in the past two decades, MacKay's attempt to trace a path between interactionism and materialism is still worth considering. (shrink)

The collection presents a variety of promising new directions in Royce scholarship from an international group of scholars, including historical reinterpretations, explorations of Royce's ethics of loyalty and religious philosophy, and contemporary applications of his ideas in psychology, the problem of reference, neo-pragmatism, and literary aesthetics.

Proteolytic cleavage of extracellular matrix (ECM) is a critical regulator of many physiological and pathological events. It affects fundamental processes such as cell growth, differentiation, apoptosis and migration. Most proteases are produced as inactive proenzymes that undergo proteolytic cleavage for activation. Proteolytic activity is additionally modified by endogenous inhibitors. Mechanisms that localize and concentrate protease activity in the pericellular microenvironment of cells are prerequisites for processes like angiogenesis, bone development, inflammation and tumor cell invasion. Methods that enable real‐time, high‐resolution imaging (...) and precise quantification of local proteolytic activity in vitro and in vivo remain major challenges. These methods will play an important role in the understanding of basic principles e.g. in cancer cell invasion, the identification of new therapeutical targets and hence drug design. This review highlights mechanisms and functions of local proteolytic activity with special emphasis on tumor cell invasion and metastasis, and focuses on techniques for the investigation of this process. BioEssays 27:1181–1191, 2005. © 2005 Wiley Periodicals, Inc. (shrink)

What would a visual image of a philosophical idea look like? Aren't philosophical concepts, by virtue of their very abstractness, incapable of being rendered visually? These are some of the questions raised in this catalogue of an exhibition at the Mount Holyoke College Art Museum, Mel Bochner: Illustrating Philosophy, which examines a specific project by the renowned conceptual artist. Curator and author Thomas E. Wartenberg explores Bochner's prints and drawings inspired by the writings of philosopher Ludwig Wittgenstein, a (...) suite of which was published as illustrations to the 1991 Arion Press edition of On Certainty. Through his sensitive analysis, Wartenberg shows how Bochner translates Wittgenstein's revolutionary claims about knowledge and doubt into visual images. Bochner's work presents an important corrective to a view of book illustrations as a crutch for understanding an author's meaning. Illustrations, in fact, can provide an alternative means of access to complex, even abstract ideas. This book will interest an academic audience, particularly in the areas of philosophy, art and art history, linguistics, and word and image studies. (shrink)

G.E. Moore, more than either Bertrand Russell or Ludwig Wittgenstein, was chiefly responsible for the rise of the analytic method in twentieth-century philosophy. This selection of his writings shows Moore at his very best. The classic essays are crucial to major philosophical debates that still resonate today. Amongst those included are: * _A Defense of Common Sense * Certainty * Sense-Data * External and Internal Relations * Hume's Theory Explained * Is Existence a Predicate? * Proof of an External (...) World In addition, this collection also contains the key early papers in which Moore signals his break with idealism, and three important previously unpublished papers from his later work which illustrate his relationship with Wittgenstein._. (shrink)

These are replies to the discussions by Kirk Ludwig, Elizabeth Pacherie, Björn Petersson, Abraham Roth, and Thomas Smith of Michael E. Bratman, Shared Agency: A Planning Theory of Acting Together (Oxford University Press, 2014).

This anthology of readings in the survey of Western philosophy--from the Ancient Greeks to the 20th Century--is designed to be accessible to today's readers. Striking a balance between major and minor figures, it features the best available translations of texts--complete works or complete selections of works-- which are both central to each philosopher's thought and are widely accepted as part of the canon. The selections are readable and accessible, while still being faithful to the original. Includes Introductions to each historical (...) period and to each philosopher, and an abundance of drawings, diagrams, photographs, and a timeline. This Combined Volume contains the most important works from Baird's Philosophic Classics, Volumes I-V. ANCIENT GREEK PHILOSOPHY. Plato. Aristotle. HELLENISTIC PHILOSOPHY. Epicurus. Epictetus. Plotinus. MEDIEVAL PHILOSOPHY. Augustine. Boethius. Anselm (and Guanilo). Moses Maimonides. Thomas Aquinas. William of Ockham. Pico Della Mirandola. MODERN PHILOSOPHY. Ren Descartes. Thomas Hobbes. Blaise Pascal. Baruch Spinoza. John Locke. Gottfried Leibniz. George Berkeley. David Hume. Immanuel Kant. NINETEENTH-CENTURY PHILOSOPHY. G.W.F. Hegel. John Stuart Mill. Soren Kierkegaard. Karl Marx. Friedrich Nietzsche. TWENTIETH-CENTURY PHILOSOPHY. Edmund Husserl. Bertrand Russell. Martin Heidegger. Ludwig Wittgenstein. A.J. Ayer. Jean-Paul Sartre. Willard Van Orman Quine. Jacques Derrida. For anyone interested in Philosophy, History of Philosophy, or History of Intellectual Thought. (shrink)

A book of readings in Western intellectual history focusing on the role of reason in human action. Contents:^ Plato: Myth of the Cave; Plato: ^IThe Four Virtues; Aristotle: Knowledge of Causes; Aristotle: The Types of Governments; Epicurus: Epicureanism; Epictetus: Stoicism; St. Augustine: The Platonist; St. Augustine: The Nature of Sources of Evil; St. Thomas Aquinas: The Four Laws; St. Thomas Aquinas: The Nature of the Soul; Pico: The Oration on the Dignity of Man; John Calvin: Reason, Sin and (...) Illumination; St. Teresa of Avila: Interior Castle; Rene Descartes: Pens,s ; Thomas Hobbes: The State of Nature; John Locke: The State of Nature; Alexander Pope: Essay on Man; David Hume: Impressions and Ideas; Voltaire: Candide; Immanuel Kant: Space and Time; Immanuel Kant: The Good Will; Edmund Burke: Revolution in France; James Madison: The Federal Government; Soren Kierkegaard: Subjective Truth; Fyodor Dostoevsky: The Grand Inquisitor; Karl Marx and Friedrich Engels: Communist Manifesto; Friedrich Nietzsche: The Will to Power; William James: Pragmatism; William James: Philosophical Temperaments; Sigmund Freud: The Ego and the Id; Ludwig Wittgenstein: Later Theory; Jean-Paul Sartre: Existentialism; Carol Gilligan: Women's Place in Man's World; Appendix: Programmed Text on Epistemology. (shrink)

The institution of slavery has served to perform different functions in different societies. The distinction between ‘closed’ and ‘open’ slavery can be a useful one: in some societies slavery is a mechanism for the permanent exclusion of certain individuals from political and economic privileges, while in others it has served precisely to facilitate the integration of outsiders into the community. ‘The African slave, brought by a foray to the tribe, enjoys, from the beginning, the privileges and name of a child, (...) and looks upon his master and mistress in every respect as his new parents… by care and diligence, he may soon become a master himself, and even more rich and powerful than he who led him captive.’ The model of an ‘open’ slavery implies that service as a slave is not a state to which a person is permanently, let alone ‘naturally’, assigned, but more akin to an age-grade. A parallel might be domestic or agricultural service as it was practised in much of Europe until this century — a period spent serving in another household after childhood and prior to marriage. A Roman slave, on formal manumission, joined the community of citizens. To what extent ought we therefore to succumb to the temptation to see slavery at Rome — in contrast to the Greek world — in terms of the ideal type of a ‘process of integration’? In a noted article on ‘Die Freilassung von Sklaven und die Struktur der Sklaverei in der römischen Kaiserzeit’ , G. Alföldi argued that in the Roman Empire slavery was an ‘Übergangszustand’ , a transitional state which ultimately gave most slaves a recognised if not a fully equal place as members of the Roman citizen community. (shrink)

Bezugnehmend auf Kants Moralphilosophie entwickelt dieser Beitrag eine These dazu, was mit der Forderung gemeint sein soll, Personen unter Beachtung ihrer Würde bzw. als "Zweck an sich selbst" zu behandeln. Es wird vorgeschlagen, die Implikationen von Kants "Menschheitsformel" als ein Bündel von mit einander verwandten Vorschriften zu interpretieren, die das moralische Nachdenken darüber, wie die Prinzipien unserer tagtäglichen Entscheidungen spezifiziert und interpretiert werden sollten, leiten und begrenzen können. Der Beitrag bearbeitet sodann die folgenden drei Fragestellungen: Was folgt aus dem Vorangehenden (...) im Hinblick auf die Behandlung von Straftätern bei der Verbüßung ihrer Strafe? Was empfiehlt die "Menschheitsformel" - einmal abgesehen von Kants "offizieller" Straftheorie - im Hinblick darauf, wer, wie stark, in welcher Weise und warum bestraft werden sollte? Gibt es Konflikte zwischen diesen Empfehlungen und Kants "offizieller" Straftheorie, die eine Revision seiner Gründe für diese Theorie erforderlich machen? Drawing from Kant's moral theory, this essay develops an account of what is required to treat persons with dignity, or as "ends in themselves". It proposes to regard the implications of Kant's humanity formula as a cluster of related precepts that can guide and constrain moral deliberation about how to specify and interpret the principles that should guide day to day decisions. The essay then addresses three questions: What is implied regarding how offenders should be treated while undergoing punishment? Apart from Kant's official theory of punishment, what would the humanity formula recommend regarding who should be punished, how much, in what way, and why? Are there conflicts between these recommendations and Kant's official theory of punishment that invite reexamination of his grounds for his official theory? (shrink)

This essay, responding to recent work of David Cummiskey and Barcia Baron, defends the thesis that imperfect duty of beneficence in Kant's The Metaphysics of Morals is a rather minimal, indeterminate requirement but must be supplemented by judgement guided by the values expressed in Kant's formulas of the Categorical Imperative. So understood, Kant's ethics is neither as permissive nor as inflexibly demanding as various commentators have thought. Although Kant does not acknowledge supererogation as a moral category, arguably his position implies (...) that some acts are meritorious and more than required. (shrink)

Respect, Pluralism, and Justice is a series of essays which sketches a broadly Kantian framework for moral deliberation, and then uses it to address important social and political issues. Hill shows how Kantian theory can be developed to deal with questions about cultural diversity, punishment, political violence, responsibility for the consequences of wrongdoing, and state coercion in a pluralistic society.

A new public philosophy began to emerge in the United States during the Progressive Era. Promoted by such intellectuals as John Dewey, William James, and the coUectivists of the New Republic magazine, it called for a citizenry trained in an experimental milieu, free of dogma and emancipated from sources of allegiance other than the new centralized democratic state then being forged. Catholics, however, neither capitulated to the new creed nor retreated into a self-righteous isolation. In a culture whose chief value (...) was pluralism they insisted on the uniqueness of the Church and the need for making value judgments based on a sound philosophy of man. (shrink)

Thomas Hill, a leading figure in the recent development of Kantian moral philosophy, presents a set of essays exploring the implications of basic Kantian ideas for practical issues. The first part of the book provides background in central themes in Kant's ethics; the second part discusses questions regarding human welfare; the third focuses on moral worth-the nature and grounds of moral assessment of persons as deserving esteem or blame. Hill shows moral, political, and social philosophers just how valuable moral (...) theory can be in addressing practical matters. (shrink)

It is a violation of legitimate academic freedom to attempt to link Catholicism to a particular school of economic thought and shut down all further debate. Whether the realm of human choice, which economics describes, is subject to an array of cause-and-effect relationships is obviously a matter for human reason to determine. From there, reason can then investigate these relationships. Although economic policy has a moral dimension, economics as a positive scienceconsists merely of an edifice of cause-and-effect relationships, and to (...) that extent is as autonomous as the purely descriptive sides of all other sciences. (shrink)

This is the text of The Lindley Lecture for 2006, given by Thomas E. Hill, Jr., an American philosopher.

This response considers the question whether empiricists are condemned to silence about the epistemic agency their theories attribute or presuppose. It is argued that, unlike Reichenbach or Carnap, Neurath allowed for and indeed provided specifications of the role of epistemic agency in scientific inquiry. If this is correct, it underscores once more the need to distinguish between the various strands of logical positivism which show different strengths and weaknesses.

Distinguishes basic and more extreme ideas underlying three related Kantian themes: that fundamental questions of moral philosophy require an a priori method, that moral duties are conceived as categorical imperatives, and that moral agents have autonomy of the will. Arguably, an a priori method is needed for analysis and assessment of rationality claims, and we can act on moral reasons implicit in the humanity formula without a sense of constraint or an objectionably impartial attitude. The idea of a noumenal world (...) is not a premise of Kantian ethics, but a conclusion to which Kant thought his ethics inevitably led. (shrink)

Contrasts common‐sense ideas of what is reasonable with current philosophical ideas of rational choice: maximizing self‐interest, efficiency and coherence in pursuit of one's ends, maximizing intrinsic value, and efficiency and coherence constrained by a Kantian ideal of co‐legislation. Contrary to the usual assumptions, the last corresponds more closely to common‐sense ideas than any of the other models do. This is not a proof of the Kantian ideal, or of common sense, but it calls for rethinking assumptions about self‐regarding and other‐regarding (...) reasons for action. (shrink)

Originally published by J. T. Edlen von Trattnern.

Thomas E. Hill, Jr.; Servility and Self-Respect, The Monist, Volume 57, Issue 1, 1 January 1973, Pages 87–104, https://doi.org/10.5840/monist197357135.

“Supererogation” is now a technical term in philosophy for a range of ideas expressed by terms such as “good but not required,” “beyond the call of duty,” “praiseworthy but not obligatory,” and “good to do but not bad not to do” (see Duty and Obligation; Intrinsic Value). Examples often cited are extremely generous acts of charity, heroic self-sacrifice, extraordinary service to morally worthy causes, and sometimes forgiveness and minor favors. These concepts are familiar in institutional contexts, for example, when teachers (...) give points for “extra credit” work, corporations give “bonuses” for profitable leadership, and armies award medals for extraordinary service and valor. Moral philosophers, however, have generally focused on whether or not some of these terms refer to a fundamental moral category and, if so, how the category should be defined, which acts the category includes, and whether various moral theories adequately acknowledge it. The idea that acts can be good and praiseworthy but beyond duty has seemed puzzling for several reasons. For example, it seems that “good and praiseworthy” appeals to scalar standards of (“more or less”) value and virtue whereas “duty,” “required,” and “obligatory” invoke nonscalar norms that make (“all or nothing”) demands. This raises the theoretical question whether morality presupposes two distinct conceptual schemes, and, if so, to what extent and how these can be unified in a consistent and coherent moral theory. (shrink)

Tacitus is an unlikely source for our study of Brutus, Cassius, and Cato, as they stand outside the chronological framework of Tacitus’ writings; nonetheless, they do appear a number of times throughout his works, and Tacitus portrays them with nuance and significance. As Brutus, Cassius, and Cato are rarely the precise focus for Tacitus, they are often referred to obliquely or in dialogue or speeches typically regarding treason and liberty. This paper will explore Tacitus’ depiction of Brutus, Cassius, and Cato (...) in his major and minor works, including the oblique references to Cato, Brutus as an orator and writer, Brutus and Cassius as commanders in civil war, and lastly their memory as it pertains to liberty and treason. Tacitus’ contribution to our understanding of Brutus, Cassius, and Cato comes from both his own use of them as markers of political memory and liberty and his examination of how others used Brutus, Cassius, and Cato to make arguments for political liberty or for the basis of accusations of treason. (shrink)

James Fitzjames Stephen is remembered as a judge, legal historian, and the author of Liberty, Equality, Fraternity, a reply to J. S. Mill's late works. He is less well remembered for his journalism, though it earned him a reputation among his contemporaries as one of the most trenchant writers on topics ranging across the social, religious, political, moral, and philosophical questions debated in his time. It was largely in his journalistic writing that Stephen set forth his views on these questions. (...) Despite such a reputation, however, only a small proportion of this writing was collected during his lifetime, and very little has been republished since his death.Selected Writings of James Fitzjames Stephen: On Society, Religion, and Government includes thirty-five essays expressing Stephen's views on the questions of his day, which have not lost their interest in ours. He wrote at a time when much of the finest writing in English was published in periodicals, often anonymously. The essays in this volume are drawn mostly from Stephen's unsigned contributions to the Saturday Review, with additions, both signed and unsigned, from other periodicals, extending from the 1850s to the 1880s. (shrink)

In this book Thomas Wren uncovers and assesses the largely hidden philosophical assumptions about human motivation that have shaped contemporary psychological ...

The purpose of this essay is to illustrate the concept of analogy in the late works of St. Thomas Aquinas, i.e., in his two Summas, and to go on to compare this with Ludwig Wittgenstein's concept of “family resemblance”, in order to reveal some interesting similarities between the named linguistic-philosophical concepts of these two very different thinkers.

The properties of disulphide bonds relevant to their roles in stabilizing protein conformation are reviewed. Natural disulphides can stabilize folded conformations substantially, in some cases to much greater extents than would be expected from just entropic effects on the unfolded state. The linkage relationship between conformational stability and disulphide stability is illustrated. Disulphides will not, however, increase protein stability if the disulphides are not maintained in the unfolded state or if instability is caused by processes, such as chemical modification or (...) proteolysis, that are not linked to unfolding, either local or global. This is part of the reason why some recent attempts to increase protein stability by introducing new disulphides have had only modest success. Other reasons appear to be the severe energetic constraints on disulphide bond geometry and, in some cases, unfavourable effects of introducing Cys residues by mutation. (shrink)

There are many ways of writing about the moral life, but at first sight few seem more formal and apparently remote from its urgent, anguishing problems than ...

This is followed by a section about action in general: it establishes the standpoint of the agent and makes an inventory of several species of action.

I examine the thesis that Otto Neurath anticipated the programme of naturalised epistemology already at the time of the Vienna Circle and consider the relation between Neurath's proposals and those of two contemporary theorists whose research programmes he would thus have broadly anticipated. The thesis is confirmed by reference to Neurath's own writings. The connection between Neurath's programme and the programmes of his two successors considered here, however, is found to be highly indirect in one case and nonexistent in the (...) other — despite their undeniable overlap. (shrink)